Muscle mass
Muscle mass on GLP-1 receptor agonists
Lean-mass loss is the most-cited body-composition concern with GLP-1 receptor agonist therapy. The published trial data put the proportion of total weight loss attributable to lean tissue in the 25–40% range — a figure consistent with what is observed in non-pharmacologic rapid weight loss, but at scale across millions of new patients now on these medications. Resistance training and protein adequacy are the two consistently-cited modifiable inputs.
Tracking muscle-mass changes on GLP-1: a practical follow-up framework
A practical follow-up framework for tracking muscle-mass changes on GLP-1: body-composition measurement (DXA or BIA), functional measures (grip strength, chair-stand), engagement metrics (protein intake adequacy, resistance-training frequency), and how to interpret the trend with the clinician.
Older adults on GLP-1: sarcopenia risk and muscle-preservation focus
GLP-1 use in older adults is increasing. Higher baseline sarcopenia risk, anabolic resistance, and the consequences of lean-mass loss in this population. Higher protein targets and resistance-training engagement matter more here than in younger patients.
DXA, BIA, and other body-composition tools for GLP-1 follow-up
DXA scans, MRI, bioelectrical impedance (BIA), and anthropometric methods for body-composition tracking on GLP-1. What each measures, what the limitations are, and how to integrate body-composition follow-up with clinical care.
Resistance training while on GLP-1: practical programming
What 'resistance training' actually means in the muscle-preservation context. Practical programming for GLP-1 patients: 2-3 sessions per week, progressive, covering major muscle groups. Considerations for reduced energy availability, dose-day timing, and training tolerance.
Lean mass loss on GLP-1: what the evidence actually shows
What the published trial body-composition substudies show about lean-mass loss on semaglutide and tirzepatide. The 25-40% range. Variability across studies. Known mitigations: protein adequacy and resistance training. Hedged interpretation for clinical practice.